姓名： 张春云
职称、职务： 教授
电子邮箱： cyzhang@hubu.edu.cn
通信地址：武汉市武昌区友谊大道368号BEVITOR伟德
联系电话：027-88661699-8056
主要研究方向
环境分析与毒理：（1）环境污染物的非靶标分析；（2）环境污染物的生物转化；（3）环境污染物暴露代谢组学
教育背景
2007.09-2010.06 齐鲁工业大学, 轻化与环境工程学院, 学士
2010.09-2015.06 华南理工大学, 轻工与食品学院, 博士
工作经历
2015.08-2018.04 中国科学院武汉植物园 助理研究员
2018.04-2021.04 美国爱荷华大学 职业与环境卫生系 博士后
2021.07-2021.12 中国科学院武汉植物园 副研究员
2022.01- BEVITOR伟德 BEVITOR伟德 教授
教学课程
污染物监测与评价、污染物监测与评价实验
主要社会兼职
Environ. Sci. & Technol., J. Hazard. Mater., Anal. Chem., J. Chromatogr. A等期刊审稿人
荣誉和获奖情况
2014年，获得华南理工大学优秀博士论文创新基金二等资助；
2008年，获得国家励志奖学金；
承担（主持）的主要科研项目
1. 武汉市知识创新专项基础研究项目，2022/06-2024/06，主持；
2. 美国国立卫生研究院（NIH）通过爱荷华大学环境与健康科学研究中心（EHSRC）资助的试点项目，2020/04-2021/04，主持；
3. 国家自然科学基金青年基金，3160180020，2017/01-2019/12，主持；
4. 湖北省自然科学基金，2016CFB285, 2016/01-2017/12，主持；
5. 国家自然科学基金面上项目，81673580，2017/01-2020/12，参加。
代表作（*通讯作者）
（一）代表性论文：
1. Chun-Yun Zhang, Xueshu Li, Kimberly P. Keil Stietz, Sunjay Sethi, Weizhu Yang, Rachel F. Marek, Xinxin Ding, Pamela J. Lein, Keri C. Hornbuckle, Hans-Joachim Lehmler*. Machine Learning-Assisted Identification and Quantification of Hydroxylated Metabolites of Polychlorinated Biphenyls in Animal Samples. Environmental Science & Technology 2022, DOI: 10.1021/acs.est.2c02027.
2. Chun-Yun Zhang, Xueshu Li, Susanne Flor, Patricia Ruiz, Anneli Kruve, Gabriele Ludewig, Hans-Joachim Lehmler*. Metabolism of 3‑Chlorobiphenyl (PCB 2) in a Human-Relevant Cell Line: Evidence of Dechlorinated Metabolites. Environmental Science & Technology 2022, DOI: 10.1021/acs.est.2c03687.
3. Chun-Yun Zhang, Susanne Flor, Patricia Ruiz, Gabriele Ludewig, Hans-Joachim Lehmler*. Characterization of the Metabolic Pathways of 4-Chlorobiphenyl (PCB3) in HepG2 Cells Using the Metabolite Profiles of Its Hydroxylated Metabolites. Environmental Science & Technology 2021, 55, 9052-9062.
4. Chun-Yun Zhang, Susanne Flor, Gabriele Ludewig, Hans-Joachim Lehmler*. Atropselective partitioning of polychlorinated biphenyls in a HepG2 cell culture system: experimental and modeling results. Environmental Science & Technology 2020, 54, 13817-13827.
5. Chun-Yun Zhang, Susanne Flor, Patricia Ruiz, Ram Dhakal, Xin Hu, Lynn M. Teesch, Gabriele Ludewig, Hans-Joachim Lehmler*. 3,3’-Dichlorobiphenyl is metabolized to a complex mixture of oxidative metabolites, including novel methoxylated metabolites, by HepG2 cells. Environmental Science & Technology 2020, 54, 12345-12357.
（二）其它论文：
6. Chun-Yun Zhang, Teng-Fei Li, Xin-Sheng Chai*, Xian-Ming Xiao. Determination of porosity in shale by double headspace extraction GC analysis. Analytical Chemistry 2015, 87, 11072-111077.
7. Chun-Yun Zhang, Qiong Zhang, Cai-Hong Zhong, Ming-Quan Guo*. Volatile fingerprints and biomarkers of three representative kiwifruit cultivars obtained by headspace solid-phase microextraction gas chromatography mass spectrometry and chemometrics. Food Chemistry 2019, 271, 211-215.
8. Chun-Yun Zhang, Neng-Biao Lin, Xin-Sheng Chai*, Zhong Li. A rapid method for simultaneously determining ethanol and methanol content in wines by full evaporation headspace gas chromatography. Food Chemistry 2015, 183, 169-172.
9. Chun-Yun Zhang, Xin-Sheng Chai*, Xian-Ming Xiao. A simple method for correcting for the presence of minor gases when determining the adsorbed methane content in shale. Fuel 2015, 150:334-338.
10. Chun-Yun Zhang#, Meng-Hui Li#, Ming-Quan Guo*. A phase conversion headspace technique for the determination of anti-anaerobic activity of drug candidate based on the metabolic acidity change in culture medium. Journal of Chromatography A 2020, 1621, 461024.
11. Chun-Yun Zhang#, Meng-Hui Li#, Gui-Lin Chen, Ming-Quan Guo*. In-situ headspace analysis of metabolic carbon dioxide of aerobic bacteria for assessing antimicrobial activity of natural products. Journal of Chromatography A 2019, 1600, 41-45.
12. Chun-Yun Zhang, Ming-Quan Guo*. Solvent-saturated solid matrix technique for increasing the efficiency of headspace extraction of volatiles. Journal of Chromatography A 2017, 1511, 9-14.
13. Chun-Yun Zhang, Qiong Zhang, Cai-Hong Zhong, Ming-Quan Guo*. Analysis of volatile compounds responsible for kiwifruit aroma by desiccated headspace gas chromatography-mass spectrometry. Journal of Chromatography A 2016, 1440:255-259.
14. Chun-Yun Zhang, Xin-Sheng Chai*. A novel multiple headspace extraction gas chromatography method for measuring the diffusion coefficient of methanol in water and olive oil. Journal of Chromatography A 2015, 1385:124-128.
15. Chun-Yun Zhang, Hui-Chao Hu, Xin-Sheng Chai*, Pan Lei, Xian-Ming Xiao. Determination of maximal amount of minor gases adsorbed in a shale sample by headspace gas chromatography. Journal of Chromatography A 2014, 1328:80-84.
16. Chun-Yun Zhang, Ling-Ling Li, Xin-Sheng Chai*, Donald G. Barnes. Rapid determination of methanol content in paper materials by alkaline extraction coupled with headspace analysis. Journal of Chromatography A 2014, 1350:10-14.
17. Chun-Yun Zhang, Hui-Chao Hu, Xin-Sheng Chai*, Pan Lei, Xian-Ming Xiao. A novel method for the determination of adsorption partition coefficient of minor gases in a shale sample by headspace gas chromatography. Journal of Chromatography A 2013, 1310:121-125.
18. Chun-Yun Zhang, Neng-Biao Lin, Xin-Sheng Chai*, Zhong Li. Rapid determination of titratable acidity in wines by headspace analysis. Food Analytical Methods 2015, 8:893-897.
19. Chun-Yun Zhang, Ming-Quan Guo*. Analysis and differentiation of the volatile compounds in red and white wines using desiccated headspace gas chromatography-mass spectrometry coupled with chemometrics. Food Analytical Methods 2017, 10, 3531-3537.
20. Chun-Yun Zhang, Xin-Sheng Chai*, Donald G. Barnes. A novel solvent-assisted vapor absorption based headspace analysis technique for the determination of diffusion and solid-air partition coefficients of methanol in paper food packaging materials. Fluid Phase Equilibria 2015, 150:334-338.
21. Chun-Yun Zhang, Carolyn R. Klocke, Pamela J. Lein, Hans-Joachim Lehmler*. Disposition of PCB 11 in Mice Following Acute Oral Exposure. Chemical Research in Toxicology 2021, 34, 988-991.
22. Chun-Yun Zhang, Dan Fu, Gui-Lin Chen, Ming-Quan Guo*. Comparative and chemometric analysis of correlations between the chemical fingerprints and anti-proliferative activities of ganoderic acids from three Ganoderma species. Phytochemical Analysis 2019, 30, 474-480.
23. Yong-Qiang Tian#, Chun-Yun Zhang#, Ming-Quan Guo*. Comparative study on alkaloids and their anti-proliferative activities from three Zanthoxylum species. BMC Complementary and Alternative Medicine 2017, 17, 460.
24. Menghui Li#, Chunyun Zhang#, Guilin Chen, Lutfun Nahar, Satyajit D. Sarker, Mingquan Guo*. Headspace gas chromatographic method for antimicrobial screening: Minimum inhibitory concentration determination. Journal of Pharmaceutical and Biomedical Analysis 2020, 181, 113122. (#Co-First Author)
25. Xueshu Li, Chunyun Zhang, Kai Wang, Hans-Joachim Lehmler*. Fatty liver and impaired hepatic metabolism alter the congener-specific distribution of polychlorinated biphenyls (PCBs) in mice with a liver-specific deletion of cytochrome P450 reductase. Environmental Pollution, 2020, 266, 115233.
26. Riann Jenay Egusquiza, Maria Elena Ambrosio, Shuyi Gin Wang, Kaelen Marie Kay, Chunyun Zhang, Hans-Joachim Lehmler, Bruce Blumberg*. Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice. Environmental Health Perspectives, 2020, 128, 047011.
27. Jing Li, Chun-Yun Zhang, Hui-Chao Hu, Xin-Sheng Chai*. Effect of shortening kraft pulping integrated with extended oxygen delignification on bio-refinery process performance of eucalyptus. Bioresource Technology, 2016, 202, 11-124.
28. Yong-Qiang Tian, Chun-Yun Zhang, Ming-Qiang Guo*. Comparative analysis of Amaryllidaceae alkaloids from three Lycoris species. Molecules, 2015, 20, 21854-21869.
29. Mingzhi Zhu, Ting Liu, Chunyun Zhang, Ming-Quan Guo*. Flavonoids of Lotus (Nelumbo nucifera) seed embryos and their antioxidant potential. Journal of Food Science, 2017, 82, 1834-1841.
30. Hui-Chao Hu, Xin-Sheng Chai, Chun-Yun Zhang, Li-Ming Fu, Donald Barnes, Liu-Lian Huang, Li-Hui Chen*. Experimental and kinetic model of methanol formation during oxygen delignification processes of alkaline pulps for air emission control. Holzforchung, 2015, 69, 933-942.
31. Qingqing Guan, Minli Wang, Hua Shang, Chunyun Zhang, Chaohai Wei, Ping Ning, Junjie Gu, Xin-Sheng Chai* Rapid determination of ethyl laurate from supercritical ethanol-carbon dioxide transesterification by full evaporation headspace gas chromatography. Energy & Fuels, 2014, 28, 6995-6998.
32. Derek Simonsen, Nicole Cady , Chunyun Zhang, Rachel L Shrode, Michael L McCormick, Douglas R Spitz, Michael S Chimenti, Kai Wang, Ashutosh Mangalam, Hans-Joachim Lehmler. The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice. Toxicological Sciences 2021, doi: 10.1093/toxsci/kfab142.
（三）专利
1. 张春云, 郭明全, 李梦辉. 天然产物对厌氧菌抗菌活性的测定方法及应用, 2020, 中国发明专利, 202010149072.8.
2. 张春云, 郭明全, 李梦辉. 一种用于生物培养的厌氧瓶定量等压除氧装置及方法, 2020, 中国发明专利, 202010283126.X.
3. 郭明全, 陈桂林, 田永强, 张春云. 一种快速筛选天然产物中拓扑异构酶I抑制剂的方法, 2017, 中国发明专利, ZL201610249760.5.
（四）学术报告
1. Chun-Yun Zhang. Airborne polychlorinated biphenyls: metabolism and associated metabolomic alterations. EHSRC/Superfund/Toxicology seminar, Invited Oral Presentation, University of Iowa, Iowa City, Iowa, USA, Apr 02, 2021.
2. Chun-Yun Zhang, Susanne Flor, Gabriele Ludewig, Hans-Joachim Lehmler. Elucidation of the metabolic pathways of 4-chlorobiphenyl (PCB3) in HepG2 cells using a set of hydroxylated metabolites. Central States Chapter of the Society of Toxicology 2020 Annual Meeting, Short Oral presentation, Virtual Platform, Oct 16, 2020.
3. Chun-Yun Zhang, Susanne Flor, Gabriele Ludewig, Hans-Joachim Lehmler. Metabolite profiles of a set of hydroxylated metabolites facilitate the identification of the metabolic pathways of 4-chlorobiphenyls (PCB 3) in HepG2 cells. 2020 Annual Meeting of Superfund Research Program, Poster presentation. Virtual Platform, Dec 15, 2020.
4. Chun-Yun Zhang, Susanne Flor, Gabriele Ludewig, Hans-Joachim Lehmler. Enantioselective partitioning of polychlorinated biphenyls (PCBs) in a HepG2 cell culture system. Central States Chapter of the Society of Toxicology 2019 Annual Meeting, Poster presentation, Drake University, Des Moines, Iowa, USA, Sep 27, 2019.
5. Chun-Yun Zhang, Susanne Flor, Ram Dhakal, Xueshu Li, Lynn M. Teesch, Gabriele Ludewig, Hans-Joachim Lehmler. Metabolism of non-Aroclor 3,3’-dichlorobiphenyl (PCB 11) in human hepatoma (HepG2) cells. Central States Chapter of the Society of Toxicology 2018 Annual Meeting, Poster presentation, Kansas State University, Manhattan, Kansas, USA, Oct 18-19, 2018.
其它
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